Along with CBD and THC, scientists and researchers are analyzing the importance of another lesser-known cannabinoid called CBG. It is believed to be sharing beneficial characteristics with CBD. Both these cannabinoids are non-toxic and boast antioxidative, analgesic, and neuroprotective qualities. CBG and CBD together offer anti-inflammatory characteristics to treat neuroinflammation.
What is CBG?
Cannabigerol or CBG is amongst the 120 cannabinoids founded in cannabis and was isolated from the rest in 1964. It presently comprises qualities to fight cancer, bacteria’s, and depression. The Cannabigerolic acid (CBGA) is a chemical parent to cannabinoids. It’s analgesic properties might transcend those of THC and not cause the intoxicating hit. The maturation and growth process of the cannabis plant causes the enzymes to convert CBGA into three elemental acids, namely tetrahydrocannabinol acid (THCA), cannabidiolic acid (CBDA), and cannabichromenic acid (CBCA). The acid becomes CBG through the process of decarboxylation. Research suggests that CBG has partial sympathy towards CB1 and CB2 receptors, but also bind to other endocannabinoid physiological pathways. It is believed to activate receptors of heat sensitivity, influence pain, and inflammation. Most cannabis plants acquire low levels of CBG, and those which are dominant by CBG are called “Type IV” cannabis plants, although they are rarely found in cannabis markets. Plants with a higher concentration of CBG make it easier to extract cannabinoids for medical usage.
Extraction of CBG
Unlike any other cannabinoid, CBG is also extracted from the hemp plant or cannabis flower with the help of ethanol or CO2. From here on, the plant matter and other impurities and oil are gotten rid of through the process of distillation, with steam. The resulting solution is a honey-like distillate, which is believed to be the purest form of CBG. From there on, it can be used to produce a wide array of products.
Both CBG and CBD are available to purchase online mode. Although, cannabis-based products are still highly illegal and prohibited for usage in most states, but also available in many. On the other hand, hemp-based products are legally available in almost every country. One can purchase these from online shopping sites like Amazon, and they are available in a maximum of 750mg bottles. By purchasing these CBG, you can leverage every potential benefit it’s compounds have to offer. Buy it from a reputable dealer and diligently ask for third party quality testing.
What is CBD?
Cannabidiol or CBD is a cannabinoid found in Type II and Type III cannabis and hemp plants, isolated from the rest in the late 1930s. Researchers have discovered the health effects of pure CBD in curing childhood epilepsy. It might also boast anti-inflammatory and analgesic properties. It renders abilities to fight against anxiety, nausea and may offer sedating qualities. CBD mixed with THC provides many significant therapeutic benefits, called the entourage effect. There are many different CBD gummies available in the market about which one can read more information on https://www.ecowatch.com/best-cbd-gummies-2020-2647537750.html.
CBG vs. CBD
- Molecular structure
Cannabigerol and Cannabidiol comprise different molecular structures, meaning the hydrogen, oxygen, and carbon molecules that make up a cannabinoid, are different in both of them. This distinction means that both these cannabinoids acquire dissimilar three-dimensional shapes, therefore they act on bodies differently because of their bonding process with the body’s cannabinoid receptors distinctively. Both it’s molecular structure determines its degree of solubility in the water and the overall bioavailability of the cannabinoid.
- Pharmacology
A 2011 psychopharmacology study proved that CBG and CBD activated receptors differently. It was analyzed by activating the 5-HT1A serotonin receptor, by both these cannabinoids. It was observed that CBD exerted its anti-nausea effects and acted as an agonist on the 5-HT1A serotonin receptor, whereas, CBG acted as an antagonist (blocker) at the 5-HT1A serotonin receptor. Consequently, it was proven that CBG blocked CBD’s anti-nausea effects, portraying the differing functions of both the cannabinoids and their opposing actions on the same receptor in that particular study.
- Appetite stimulation
Another elemental way that both these cannabinoids differ was proven in a study on rats, where doses of CBG rose their hunger more than double and made them eat a lot. In another study, CBG didn’t induce as much change in their hunger, but CBD doses significantly reduced their overall food intake.
Therapeutic benefits of CBG!
Although there are no clinical trials that prove the benefits of CBG on humans, several preclinical trials have proven so. CBG does not help an individual feel psychoactive and intoxication, it does cause therapeutic benefits and fight diseases such as Huntingdon’s disease, inhibiting tumor growth, treating glaucoma, decreasing inflammation, and combatting drug-resistant bacteria. Amongst these, there are many other medical benefits of CBG, such as:
MRSA bacterial infections:
In a study, CBG defeated other cannabinoids and became an effective and powerful vancomycin, a powerful antibacterial remedy.
Cancer:
CBG encompasses properties to fight against cancer cells due to its inhibits of abnormal cell proliferation. The inhibition of mouse skin melanoma cells provides evidence of its antitumorigenic traits.